I have to hand it to you; this picture is pretty interesting,
The mane style you used for Fluttershy is amazing here. It looks very professional and true to the name, suits it's theme.
Lets see... The first thing that comes to mind is the lovely posture Fluttershy the Secretary is in. You've got some good form on the body, despite her standing on two hooves instead of the usual four. I also really like the shading on her mane. It all looks pretty well done. Speaking of the mane, I love the addition of the butterfly thing that's holding it in a ponytail.
The setting/background isn't too much to look at. It's simplistic enough to add to the art piece, but not too distracting to draw away from the center of the piece; Fluttershy.
Overall this is a very interesting piece. There's not really anything I see that could use improvement.
Yeah, hey Fluts, when you get a minute, can you get me a coffee with five doses of insulin? Four isn't enough, I feel a heart attack coming on... Bring some just in the syringes too, I'll probably need one when you come in with the java. Ugh... It's gonna be a long night at the office.